Research

Our research bridges the realms of chemistry and biology. By employing multidisciplinary techniques, including organic synthesis, bioorthogonal chemistry, directed evolution, and genetic code expansion, we developed a series of methodologies for constructing, modifying, and precisely regulating functional molecules at the small and macromolecular levels. These innovative approaches are beneficial for discovering new bioactive compounds and deepening our understanding of complex biochemical processes within living organisms, thereby holding significant value for both innovation and practical application in medicine and drug development.

Highlighted

Genetically encoded bioorthogonal tryptophan decaging in living cells
Genetically encoded bioorthogonal tryptophan decaging in living cells
Yuchao Zhu, Wenlong Ding, Yulin Chen, Ye Shan, Chao Liu, Xinyuan Fan, Shixian Lin, Peng R. Chen
Nature Chemistry  ·  28 Feb 2024  ·  doi:10.1038/s41557-024-01463-7
Genetically encoded bioorthogonal tryptophan decaging enables ondemand activation of over 20000 proteins in living cells.
Manubot
Manuscript Source
Website
open-science collaboration

All

2024

Bioorthogonal Cleavage Chemistry: Harnessing the Bond‐Break Reactions for Biomolecule Manipulations in Living Systems
Bioorthogonal Cleavage Chemistry: Harnessing the Bond‐Break Reactions for Biomolecule Manipulations in Living Systems
Yuchao Zhu, Feng Lin, Ziqi Liu, Xin Wang, Shubing Wang, Xinyuan Fan, Peng R. Chen
Chinese Journal of Chemistry  ·  26 Dec 2024  ·  doi:10.1002/cjoc.202400876
Genetically encoded bioorthogonal tryptophan decaging in living cells
Genetically encoded bioorthogonal tryptophan decaging in living cells
Yuchao Zhu, Wenlong Ding, Yulin Chen, Ye Shan, Chao Liu, Xinyuan Fan, Shixian Lin, Peng R. Chen
Nature Chemistry  ·  28 Feb 2024  ·  doi:10.1038/s41557-024-01463-7
Genetically encoded bioorthogonal tryptophan decaging enables ondemand activation of over 20000 proteins in living cells.
Manubot
Manuscript Source
Website
open-science collaboration

2020

DMSO‐Enabled Selective Radical O−H Activation of 1,3(4)‐Diols
DMSO‐Enabled Selective Radical O−H Activation of 1,3(4)‐Diols
Yuchao Zhu, Ziyao Zhang, Rui Jin, Jianzhong Liu, Guoquan Liu, Bing Han, Ning Jiao
Angewandte Chemie International Edition  ·  01 Sep 2020  ·  doi:10.1002/anie.202007187

2019

DMSO-catalysed late-stage chlorination of (hetero)arenes
DMSO-catalysed late-stage chlorination of (hetero)arenes
Song Song, Xinyao Li, Jialiang Wei, Weijin Wang, Yiqun Zhang, Lingsheng Ai, Yuchao Zhu, Xiaomeng Shi, Xiaohui Zhang, Ning Jiao
Nature Catalysis  ·  23 Dec 2019  ·  doi:10.1038/s41929-019-0398-0
Selective Aerobic Oxygenation of Tertiary Allylic Alcohols with Molecular Oxygen
Selective Aerobic Oxygenation of Tertiary Allylic Alcohols with Molecular Oxygen
Bencong Zhu, Tao Shen, Xiaoqiang Huang, Yuchao Zhu, Song Song, Ning Jiao
Angewandte Chemie International Edition  ·  28 Jun 2019  ·  doi:10.1002/anie.201903690
Acetonitrile Activation: An Effective Two‐Carbon Unit for Cyclization
Acetonitrile Activation: An Effective Two‐Carbon Unit for Cyclization
Qixue Qin, Xiao Luo, Jialiang Wei, Yuchao Zhu, Xiaojin Wen, Song Song, Ning Jiao
Angewandte Chemie International Edition  ·  18 Feb 2019  ·  doi:10.1002/anie.201900947

2018

From alkylarenes to anilines via site-directed carbon–carbon amination
From alkylarenes to anilines via site-directed carbon–carbon amination
Jianzhong Liu, Xu Qiu, Xiaoqiang Huang, Xiao Luo, Cheng Zhang, …, Yujie Liang, Yuchao Zhu, Qixue Qin, Song Song, Ning Jiao
Nature Chemistry  ·  29 Oct 2018  ·  doi:10.1038/s41557-018-0156-y
Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols
Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols
Yuchao Zhu, Kaimeng Huang, Jun Pan, Xu Qiu, Xiao Luo, Qixue Qin, Jialiang Wei, Xiaojin Wen, Lizhi Zhang, Ning Jiao
Nature Communications  ·  06 Jul 2018  ·  doi:10.1038/s41467-018-05014-w

2016

Fe‐Catalyzed Amination of (Hetero)Arenes with a Redox‐Active Aminating Reagent under Mild Conditions
Fe‐Catalyzed Amination of (Hetero)Arenes with a Redox‐Active Aminating Reagent under Mild Conditions
Jianzhong Liu, Kai Wu, Tao Shen, Yujie Liang, Miancheng Zou, Yuchao Zhu, Xinwei Li, Xinyao Li, Ning Jiao
Chemistry – A European Journal  ·  16 Dec 2016  ·  doi:10.1002/chem.201605476
Silver-Catalyzed Radical Transformation of Aliphatic Carboxylic Acids to Oxime Ethers
Silver-Catalyzed Radical Transformation of Aliphatic Carboxylic Acids to Oxime Ethers
Yuchao Zhu, Xiaojin Wen, Song Song, Ning Jiao
ACS Catalysis  ·  31 Aug 2016  ·  10.1021/acscatal.6b02074
Silver-Catalyzed Radical Transformation of Aliphatic Carboxylic Acids to Oxime Ethers
Silver-Catalyzed Radical Transformation of Aliphatic Carboxylic Acids to Oxime Ethers
Yuchao Zhu, Xiaojin Wen, Song Song, Ning Jiao
ACS Catalysis  ·  31 Aug 2016  ·  doi:10.1021/acscatal.6b02074

2015

Silver-Catalyzed Decarboxylative Azidation of Aliphatic Carboxylic Acids
Silver-Catalyzed Decarboxylative Azidation of Aliphatic Carboxylic Acids
Yuchao Zhu, Xinyao Li, Xiaoyang Wang, Xiaoqiang Huang, Tao Shen, Yiqun Zhang, Xiang Sun, Miancheng Zou, Song Song, Ning Jiao
Organic Letters  ·  18 Sep 2015  ·  10.1021/acs.orglett.5b02155
Silver-Catalyzed Decarboxylative Azidation of Aliphatic Carboxylic Acids
Silver-Catalyzed Decarboxylative Azidation of Aliphatic Carboxylic Acids
Yuchao Zhu, Xinyao Li, Xiaoyang Wang, Xiaoqiang Huang, Tao Shen, Yiqun Zhang, Xiang Sun, Miancheng Zou, Song Song, Ning Jiao
Organic Letters  ·  18 Sep 2015  ·  doi:10.1021/acs.orglett.5b02155
Mn-Catalyzed Highly Efficient Aerobic Oxidative Hydroxyazidation of Olefins: A Direct Approach to β-Azido Alcohols
Mn-Catalyzed Highly Efficient Aerobic Oxidative Hydroxyazidation of Olefins: A Direct Approach to β-Azido Alcohols
Xiang Sun, Xinyao Li, Song Song, Yuchao Zhu, Yu-Feng Liang, Ning Jiao
Journal of the American Chemical Society  ·  28 Apr 2015  ·  10.1021/jacs.5b02347
Mn-Catalyzed Highly Efficient Aerobic Oxidative Hydroxyazidation of Olefins: A Direct Approach to β-Azido Alcohols
Mn-Catalyzed Highly Efficient Aerobic Oxidative Hydroxyazidation of Olefins: A Direct Approach to β-Azido Alcohols
Xiang Sun, Xinyao Li, Song Song, Yuchao Zhu, Yu-Feng Liang, Ning Jiao
Journal of the American Chemical Society  ·  28 Apr 2015  ·  doi:10.1021/jacs.5b02347